The positive effect of stevia organs of the digestive system, in particular on funktsiiyu pancreas and liver (Kinghorn F., Soejarto D., 1991). In folk medicine tea from Brazil used stevia leaves with heartburn and flatulence strengthened.

Ability to use stevioside to treat diarrhea based on the bactericidal and antiviral properties of stevia extract. Furthermore, it was found that stevioside inhibits intestinal smooth muscle, the stimulation of which leads to diarrhea associated with motility (Shiozaki et al., 2006). At a concentration of 1 mM it is inhibited by 40% contraction of the isolated ileum when exposed to calcium chloride.

It is assumed that the mechanism of this phenomenon is related to its inhibitory effect on the influx of calcium into the muscle cells. Thus, stevioside may be useful in the treatment of diarrhea caused by increased intestinal motility, such as irritable bowel syndrome. However, further studies are required to prove in vivo the presence of antidiarrheal action stevia extract in hemorrhagic diarrhea, and the diarrhea associated with giperperistaltikoy.

Demonstrated therapeutic potential steviol and its analogues (digidroizosteviola) for the treatment of secretory diarrhea, initially arising from the separation of excess intestinal secretion (Pariwat et al., 2008). It is known that the secretion of fluid into the intestine is called osmosis force arising due to the secretion of active anions, especially chloride, in the gut lumen. The bacterial toxin can stimulate the active secretion of chloride and then paracellular transport of sodium and water. This hypersecretion in secretory diarrhea mediated by toxin, lead to a significant loss of water and dehydration intestine (Field, 2003). It is proved that in the line of human intestinal cells steviol, but not stevioside inhibits cAMP-activated chloride secretion (Pariwat et al., 2008).

Synthesis of analogues of steviol allowed to create a number of active compounds, of which the most pronounced digidroizosteviol reversibly inhibited cAMP-activated chloride secretion in intestinal cells (Pariwat et al., 2008). Electrophysiological and enzymatic assays showed that this compound is non-toxic and specific effect on the secretion of chloride-stimulated cAMP but not calcium. Digidroizosteviola when administered to mice infected with cholera fluid secretion in the intestine is substantially reduced. This pattern also shows that the introduction into the abdominal cavity of steviol also effectively reduces fluid secretion in the intestine. These results are consistent with the pharmacokinetic studies that indicate that the enterohepatic circulation steviol (Nakayama et al., 1986; Cardoso et al., 1996). Compounds related steviol are comparable with other antidiarrheal drugs (Muanprasat et al., 2007; Sonawane et al., 2008).